OBJECTIVES: Human immunodeficiency virus type 1 (HIV-1) infection has been detected in all provinces of China.Although epidemiological and phylogenetic studies have been conducted in many regions, such analyses are lacking from Jilin province in northeastern Sprocket China.METHOD: Epidemiological and phylogenetic analyses, as well as detection of drug-resistant mutations, were conducted on 57 HIV-1 infected patients from Changchun city identified and confirmed through annual surveillance by local Centers for Disease Control in Jilin province of northeastern China in 2012.
RESULTS: Sexual contact was determined to be the major pathway for HIV-1 transmission in Jilin, where hetero- and homosexual activities contributed almost equally.Phylogenetic analyses detected multiple subtypes of HIV-1 including subtype G circulating in Jilin, with multiple origins for each of them.Both subtype B and CRF01_AE were dominant, and evidence of subtype B transmitting between different high-risk groups was observed.
Mutations in the viral protease at position 71 indicated the presence of a selective pressure.Several drug-resistant mutations were detected, although they were predicted with low-level resistance Lighting to antiviral treatments.CONCLUSIONS: Information from this study fills the gap in knowledge of HIV-1 transmission in Changchun city, Jilin province, China.
By revealing the origin and evolutionary status of local HIV-1 strains, this work contributes to ongoing efforts in the control and prevention of AIDS.